Because the concomitance of the peculiar MS-DRB1* allelic association [13], [14], the high prevalence of the disease and the high UVR in the island, we tested the above mentioned hypothesis exploring the presence and functionality of VDREs in the promoter region of the *DRB1 alleles conferring or not an increased MS risk in the Sardinian population. This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.