FN1 and neoplasm: Strikingly, approximately more than 34% of adherent cells were detected with the M21 cells, whereas, no obvious changes were detected with the M21-L cells.These results suggested that αvβ3 integrin is indispensible for the cell adhesion facilitated by MMP2-mediated fibronectin cleavage, and that MMP-2–cleaved fibronectin promote the adhesion of tumor cells.