The expression of several molecules critical to the development of late-onset neurodegenerative diseases, such as β-amyloid (Aβ), α-synuclein, and tau, was compared between neurons differentiated from our centenarian-derived iPSCs and neurons differentiated from iPSCs derived from familial AD (FAD) and PARK4 patients. This evidence concerns the gene SNCA and familial Alzheimer disease.