We next sought to validate the microarray results pertaining to G6PD in the paired sensitive and resistant MM/MCL cell lines and establish a model system in which to interrogate the mechanistic impact of G6PD expression on 8-NH2-Ado/8-Cl-Ado activities through loss-of-function and gain-of-function studies. This evidence concerns the gene G6PD and Miyoshi myopathy.