BCL2 and plasma cell myeloma: Given the ability of 8-NH2-Ado to interfere with Mcl-1expression [9] (the primary anti-apoptotic Bcl-2 family member expressed in myeloma), this cyclin D1-BAX interaction represents a potential mechanism accounting for the association between cyclin D1 overexpression and 8-NH2-Ado resistance in myeloma cells.