Given the intractability of developing pharmacological inhibitors of transcription factors and the widespread role c-myc plays in malignant transformation, our data indicate that the intrinsic properties of 8-NH2-Ado and 8-Cl-Ado may render these compounds particularly effective in treating tumors exhibiting c-myc deregulation, such as MM [13]. This evidence concerns the gene MYC and Miyoshi myopathy.