We used a genome-wide approach to capture acetylated histone H3 K9/K14 (AcH3)-DNA interactions and interrogated the chromatin immunoprecipitation products on DNA microarrays (ChIP-chip) to determine genomic locations of AcH3 in the striatum of wild-type (WT) and transgenic (TG) R6/2 mice, a mouse model for HD [16]. The gene discussed is KRT14; the disease is Huntington disease.