FOXO1 and hepatocellular carcinoma: Consistent with our previous report and current study that MKP-3 and FOXO1 interacts and can be co-immunoprecipitated in Fao hepatoma cells [18], MKP-3 and FOXO1/FOXO1 3A can also be co-immunoprecipitated from liver lysates (Figure 6B, the second panel; Figure 6C, the second graph).