ADA and giardiasis: Apart from the apparent immunosuppressive pathway induced by the Giardia infection, several genes involved in lipid metabolism were also impacted, such as genes coding for enzymes involved in lipid synthesis or lipolysis (PLA2G1B, CYP3A5, HPGD, ADA), transcription factors regulating the lipid metabolism (PPARα, PPARγ), and the ABC transporter ABCG8, responsible for efflux of cholesterol from enterocytes into the intestinal lumen or as high-density lipoproteins in plasma.