IKZF1 and acute lymphoblastic leukemia: Although our data were only partially consistent with those reported by Mullighan et al. in children with high-risk ALL [17] and with recent gene expression profiling studies that have identified the new BCR-ABL1-like subtype [30], here for the first time we showed by ChIP analysis that Ikaros can bind in vivo the promoters of many genes differentially expressed between IKZF1 deletion and IKZF1 wild-type cases.