While different studies have established that Ikaros alterations have a pivotal role in the leukemogenesis of BCR-ABL1 positive and negative ALL [7], [11], [17], the precise mechanisms by which they promote leukemogenesis or cooperate with known molecular rearrangements (e.g. BCR-ABL1) remain to be elucidated. Here, IKZF1 is linked to acute lymphoblastic leukemia.