However, functional consequences of the deregulated expression of homeobox genes NKX3-1 and SIX6 in T-ALL remain elusive, although NKX3-1 has been described to regulate the miR-cluster 17∼92, and SIX6 the gene CDNK1B encoding cell cycle inhibitor p27 – both regulating proliferation [26], [52]. Here, SIX6 is linked to acute lymphoblastic leukemia.