In the present study, we examined normal lung tissues adjacent to surgically resected NSCLC tumors in 385 patients in order to identify IL-10 promoter SNPs at −1082A>G, −819C>T, and −592C>A by direct sequencing and polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The gene discussed is IL10; the disease is non-small cell lung carcinoma.