In the present study, markedly increased IL-6, not TGF-β and IL-23, produced by lymphocytes of spleen and draining lymph nodes in an allergen (Ova) specific manner (Figure 5and Figure S2) from mice epicutaneously sensitized with SEB and Ova was likely responsible for the enhanced Th17/IL-17 immunity that heightened the magnitude of the atopic march. Here, IL6 is linked to atopic march.