Our data above showed that epicutaneous sensitization with Ova in the presence of superantigen SEB drove the production of IL-17A in the skin, and by lymphocytes of draining lymph nodes and spleen, which was associated with exaggerated pulmonary inflammation characterized by mixed neutrophilic and eosinophilic inflammation and exaggerated AHR following Ova challenge. This evidence concerns the gene IL17A and inflammation.