We have shown in the present study that CML cells from the patients' bone marrow were engrafted in NOD/SCID mice to induce leukemia, in which human CML cells generated stromal myofibroblasts in NOD/SCID murine bone marrow, and functionally similar to that of CML cells generated in vitro in terms of their production of VEGF-A, and in supporting the proliferation to the parental CML cells. Here, VEGFA is linked to leukemia.