When CML cells were transplanted and engrafted to the irradiated NOD/SCID mice, CML cell-derived BCR-ABL-carrying myofibroblasts composed with NOD/SCID murine bone marrow stroma and made an adequate microenvironment for proliferation of parental CML cells in vivo. Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.