After 2 h postinfection with wild type 14028, no discernable interaction between AP-1 and macrophage DNA was measured but after 12 h post-infection AP-1/DNA interaction was measured and this was increased when the cells were co-cultured with IFN-γ, although this was on average 55–63% lower than that measured for the positive control. This evidence concerns the gene IFNG and infection.