NOS2 and salmonellosis: For example, iNOS-dependant induction of 8-nitroguanosine 3′,5′-cyclic monophosphate (8-nitro-cGMP) has been shown to induce heme oxygenase 1 (HO-1) which has both cytoprotective and antimicrobial effects in murine Salmonellosis [14].