A similar phenomenon has been observed in human Autoimmune Lymphoproliferative Syndrome (ALPS; Lenardo et al., 2010), most frequently through various mutations in Fas or in other molecules implicated in Fas-mediated signaling (Fisher et al., 1995; Rieux-Laucat et al., 1995). The gene discussed is FAS; the disease is autoimmune lymphoproliferative syndrome.