CD4 and neoplasm: As can be seen in Figure 2A, P1a and P4 populations represented the great majority of the tumor-infiltrating leukocyte in comparison to regulatory T- (Treg; CD4+ Foxp3+), Thelper (Th; CD4+ Foxp3-), CD8+ T, Dendritic (DC; CD11c+ MHC II+) and Natural Killer (NK; CD3- NKG2D+ DX5+) cells.