Next, we tried to identify the putative mechanisms involved in this phenomenon and we concluded that a translational blockade of Pgp expression takes place in pancreatic carcinoma cell lines, in agreement with our previous studies in colon carcinoma cell lines after TSA treatment [19] and in the human erytroleukaemia K-562 cell line [28]. This evidence concerns the gene PGP and exocrine pancreatic carcinoma.