ABCB1 and exocrine pancreatic carcinoma: To determine iHDACs effects in MDR1 mRNA expression in human pancreatic carcinoma cell lines, we analyzed the level of MDR1 mRNA by real time RT-PCR in IMIM-PC-1, IMIM-PC-2 and RWP-1 human pancreatic carcinoma cell lines in the presence and absence of TSA and SAHA.