The study presented herein has been designed to gain insight in ABCB1 regulation determining whether the translational control of Pgp functions also in pancreatic cancer cell lines, the putative regulation of ABCB1 alternative promoters by iHDACs, and whether the expression of the ABCB1 nested gene RUNDC3B interferes with the expression of the MDR1 mRNA isoforms. This evidence concerns the gene ABCB1 and familial pancreatic carcinoma.