Previous studies showed that decreased levels of CSF Aβ 1-42 less than 487 pg/mL, increased CSF phosphorylated tau (pTau 181) more than 61 pg/mL, or increased CSF total tau more than 425 pg/mL were categorized to support the diagnosis of AD, and the opposite data was against [15, 16]. This evidence concerns the gene MAPT and Alzheimer disease.