This meta-analysis of 17 case-control studies including 6378 cases and 8674 controls systematically evaluated the association between +49 A/G, −318 C/T, −1147 C/T, CT60 A/G, −1722 C/T, and rs926169 polymorphisms in the CTLA-4 gene and asthma risk. The gene discussed is CTLA4; the disease is asthma.