Compared with normal epithelia, DEC1 expression was significantly increased in low grade intraepithelial neoplasia (p<0.001), and there was also a significant difference in DEC1 expression between low grade intraepithelial neoplasia and high grade intraepithelial neoplasia (p = 0.047). Here, BHLHE40 is linked to intraepithelial neoplasia.