Two SNPs were significantly associated with risk of SCD after Bonferroni correction: SCN5A rs41312391 (relative risk [RR] 1.27, 95% confidence interval [CI] 1.11–1.45, P = 3.4×10−4) and rs2200733 in 4q25 upstream of the PITX2 gene (RR 1.28, 95% CI 1.11–1.48, P = 7.9×10−4) (Figure 1 and Table 3). The gene discussed is PITX2; the disease is Schnyder corneal dystrophy.