Furthemore, we show that blocking TNF with the pharmacological neutralizing agent Enbrel has a deleterious impact on survival of wild-type and NFATp−/− mice when administered 6 weeks rather than 12 weeks following MTb infection, with a greater impact upon NFATp−/− mice, indicating an early role for TNF derived from DC and monocytic cells in susceptibility to TB. The gene discussed is NFATC2; the disease is infection.