Given that E-cadherin acts as a tumor suppressor, whose loss is causally implicated in EMT and metastatic tumor progression [67], [68], transcriptional repression of E-cadherin by TBX2 may provide a possible mechanistic explanation for the observed EMT-inducing and pro-metastatic activities of TBX2 in breast cancer cells. The gene discussed is TBX2; the disease is metastatic neoplasm.