Efficient TBX2 knockdown was achieved in MDA-MB-435 tumor cells by stable transduction with lentiviruses expressing TBX2-specific shRNA (shTBX2), and in MDA-MB-157 cells by transient transfection with TBX2-specific siRNAs (siTBX2) (Figure 5A, 5D and 5E). Here, TBX2 is linked to neoplasm.