Concordant with this phenotype, mRNA expression of epithelial E-cadherin and ZO1 was enhanced, whereas transcription of mesenchymal genes (N-cadherin, Vimentin, Fibronectin, MMP3) was reduced in TBX2-depleted MDA-MB-435 and MDA-MB-157 breast cancer cells (Figure 5D, 5E). The gene discussed is MMP3; the disease is breast carcinoma.