CDH1 and breast carcinoma: Since we found overexpression of TBX2 to consistently reduce endogenous E-cadherin levels in normal mammary epithelial cells, and, conversely, inhibition of TBX2 to lead to enhanced E-cadherin mRNA expression in metastatic breast cancer cell lines (Table 1, Figures 1F and 5D, 5E), we revisited the question whether TBX2 could directly repress E-cadherin at the promoter level.