TBX2 and neoplasm: Notably, whereas MDA-MB-435 cells transduced with control non-target shRNA (shCtrl), or MDA-MB-157 cells transiently transfected with control scrambled siRNAs (siCtrl), had a fibroblastoid ‘spindle-like’ appearance similar to the respective parental cell lines, TBX2-depleted MDA-MB-435 and MDA-MBA-157 tumor cells displayed a ‘cobblestone-like” epithelial morphology (Figure 5B, 5C).