Of note, both primary and recurrent tumor shared identical mutations affecting exon 5 of TP53 and the R132H mutation in IDH1. The persistence of both the TP53- mutation affecting exon 5 and the IDH1- mutation together with the introduction of a partial LOH1p in the recurrent tumor strongly argue for the analysis of tumor tissue in both the analyses of the primary and the recurrent tumor. This evidence concerns the gene IDH1 and neoplasm.