As combined LOH on 1p/19q is frequently observed in pure oligodendrogliomas, potentially driven by translocation events [11], [12] and pure astrocytomas are more prone to harbor TP53 mutations, these alterations allow for the molecular distinction of tumor components of either more astrocytic or oligodendroglial lineage. The gene discussed is TP53; the disease is astrocytoma (excluding glioblastoma).