While the primary lesion AII, ID49514 revealed retained alleles for both 1p and 19q and two somatic mutations affecting exon 5 and exon 8 of the TP53- gene, upon tumor recurrence the TP53- mutation affecting exon 8 was no longer present in the tissue of the recurrent AIII, ID49516. The gene discussed is TP53; the disease is neoplasm.