On day 12, the levels of IL-1β in the hippocampus were significantly different between the hyperglycemia (F(1,34) = 24.7594, p<0.001), intrahippocampal LPS injection (F(1,34) = 46.3172, p<0.001), EX-4 treatment (F(1,34) = 8.7771, p<0.01), hyperglycemia × intrahippocampal LPS injection (F(1,34) = 5.1498, p<0.05), and hyperglycemia × intrahippocampal LPS injection × EX-4 treatment groups (F(1,34) = 4.3447, p<0.05). This evidence concerns the gene IL1B and Hyperglycemia.