For noradrenergic TH-ir neurons in the locus coeruleus (LC), significant differences were observed due to intrahippocampal LPS injection (F (1,129) = 24.1999, p<0.001; Fig. 7B & D), hyperglycemia (F (1,129) = 1240.087, p<0.001; Fig. 7C & D), and EX-4 treatment (F(1,129) = 233.7521, p<0.001; Fig. 7F & H). The gene discussed is TH; the disease is Hyperglycemia.