CD8A and neoplasm: However, while it has been previously reported by others that IL-12p70-secreting DC preparations are always better for polarizing allogeneic CD4+ T cells and for sensitizing CD8+ T cells to tumor antigens compared to DCs secreting little or no IL-12p70 [30–32], we were unable to find a superior effect of IL-12p70-producing gag mRNA-electroporated DCs to induce and expand HIV-1 gag-specific CD8+ T cells.