JAM3 and ischemia reperfusion injury: Additionally, it was observed that ischemia-reperfusion injury disrupted the localization of junctional adhesion molecule C (JAM-C) to endothelial junctions and that mice with JAM-C−/− endothelial cells demonstrated an increase in reverse transendothelial migration, reaching greater than 50% of total transendothelial migration events [10].