It has been suggested that changes of their secretion influence LH and FSH release as well as directly affect ovary steroidogenesis [11, 12, 15, 16], while PCOS-related hyperandrogenism manifests clinically by irregular menstruation, hirsutism, acne, and hair loss and frequently by infertility [17]. Here, PLOD1 is linked to polycystic ovary syndrome.