AKT2 and neoplasm: OSt was longer in patients whose tumours had strong total Akt2 expression and concurrent cytoplasmic and nuclear pAkt activity (strong Akt2 and pAkt Thr308-n+c vs. all others: 51.8 vs. 16.8 months, P=0.0009, HR 0.34, 95% CI 0.19–0.59; strong Akt2 and pAkt Ser473-n+c: 50.8 vs. 17.0 months, P=0.009, HR 0.45, 95% CI 0.26–0.78; Fig. 5).