Further, they suggest that the decrease in cell death observed in PARG-silenced cells after MNNG treatment was due to the inhibition of caspase-mediated apoptotic cell death by elevated levels of PAR.Thus, the hydrolysis of PAR by PARG appears to have a role in regulating caspase activity after DNA-damaging treatments in breast adenocarcinoma cells. Here, PARG is linked to breast adenocarcinoma.