Serine/arginine-rich splicing factor 1 (SRSF1, also termed SF2/ASF), a prototypical SR protein encoded by the gene SFRS1, has been shown to be a potent oncoprotein and is up-regulated in many cancers [5]: it is an essential factor requisite in early constitutive splicing, acting as an alternative-splicing factor capable of influencing splice-site selection [6-8]. This evidence concerns the gene SRSF1 and cancer.