Overexpression of CD44, defined by apparently increased expression of CD44 protein, has been linked to poor prognosis with tumor progression and metastatic potential in several human malignancies, including gastric cancer [7], colorectal cancer, breast cancer [5,6], uterine cancer, ovarian cancer, bladder cancer, lung cancer, hematopoietic malignancies, and gliomas [11]. Here, CD44 is linked to central nervous system cancer.