Furthermore, the present study demonstrated that RNA interference of SATB1 successfully inhibited the expression of SATB1 protein and mRNA, the growth, adhesion, invasion, metastasis and angiogenesis in vitro and tumor growth and angiogenesis in vivo, which might be the result of reducing expression of SATB1, c-Met and bcl-2 protein and increasing the expression of SLC22A18 and caspase-3. This evidence concerns the gene SATB1 and neoplasm.