CD5 and autoimmune disease: To date, the protection from autoimmune diseases in mice was linked with several unique subsets of IL-10-producing Bregs, such as CD1dHigh B1b cells (CD5− B220Low CD11b+ IgM+ CD1dHigh; Mizoguchi et al., 2002), B10 regulatory cells (IL-10-producing CD1dHigh CD5+ B cells; Yanaba et al., 2008), and CD1dHigh Tim-1+ CD5+ Bregs (Ding et al., 2011).