Further, a biomarker (soluble BAFF/BLys) produced by monocytes and dendritic cells (DCs), which is a critical B cell survival and proliferation factor, and known to be abnormally increased in contexts of autoimmunity, especially in rheumatologic diseases (Becker-Merok et al., 2006) was also been shown to be elevated in CVID patients but there was no demonstrable correlation with the incidence of autoimmunity (Knight et al., 2007). Here, TNFSF13B is linked to Autoimmunity.