The recently published Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial (ONTARGET) study compared ramipril (an ACE inhibitor), telmisartan and a combination of both drugs in 25,611 patients with vascular disease or high-risk diabetes mellitus (DM) over a median follow-up period of 56 months [58]. Here, ACE is linked to diabetes mellitus.