BDNF and amyotrophic lateral sclerosis: An alternative strategy that effectively reaches motor neurons, can exert neuroprotective properties and does not show such adverse side effects implies the use of fragment C. Osta and co-workers found in a mouse model of ALS, which carries the mutation G93A in human superoxide dismutase 1 (SOD1), transgenic SOD1G93A mice, an amelioration of the decline in hind-limb muscle innervation in the animals that were injected with either naked DNA-encoding fragment C (TTC) or naked DNA, encoding the recombinant molecule fragment C and BDNF (BDNF-TTC).