In the HA mice prefrontal cortex, significantly overrepresented pathways were the long-term potentiation, focal adhesion, NK mediated cytotoxicity, VEGF, MAPK, T cell receptor, axon guidance, regulation of actin cytoskeleton, apoptosis, Fc gamma R-mediated phagocytosis and Alzheimer's disease pathways (Table 3). The gene discussed is VEGFA; the disease is early-onset autosomal dominant Alzheimer disease.