In that sense, the levels of serum IgM, IgG, and IgA immunity to tyrosinase and to melanin, as well as the percentage of cells which could be included in immune antibody- dependent cellular cytotoxicity (ADCC), -of FcgammaRIII positive immunocompetent cells CD16+, and percentage of NK (CD16+ CD56+) positive lymphocytes as well as Fc alphaRI positive (CD89+) cells , in patients with melanoma, and in people with vitiligo, were determined and analyzed. The gene discussed is TYR; the disease is melanoma.