In accordance to the presented data, results from this work set up the question whether the additional simple approach – a diet consisting of the consummation of 50 g cooked edible mushrooms twice weekly in the meal, along with prescribed oncological therapy, might induce the appropriate effective immune response: anti-melanin or anti-tyrosinase IgM or IgG in melanoma patients patients (with low percentage of granulocytes) in order to prevent metastatic disease? Here, CD40LG is linked to metastatic neoplasm.