Enhanced levels of anti-melanin IgA autoantibodies which are preferentially found even in the presence of normal levels of FcAlphaRI (CD89) positive immunocompetent cells, in majority of melanoma patients with metastatic disease point to their disability in immunological suppression of malignant process (through ADCC) and even indicate their blocking –immunosuppressive action. The gene discussed is FCAR; the disease is melanoma.