PPARG and Cognitive impairment: Administering the PPARγ agonist, pioglitazone (Pio), to young adult male rats starting 3 days prior to, during, and for 4 or 54 weeks after the completion of a total 40 Gy dose of fWBI delivered twice a week for 4 weeks, prevented the radiation-induced cognitive impairment measured 52 weeks after fWBI (Figure 6; Zhao et al., 2007b).