Like HO-1, other Nrf2-regulated antioxidant genes such as glutamate-cysteine ligase, modifier subunit (Gclm), glutamate-cysteine ligase, catalytic subunit (Gclc), peroxiredoxin 2, glutathione peroxidase, have been shown to protect against atherosclerosis. The gene discussed is GCLM; the disease is atherosclerosis.