Interestingly, a reduction of NMDAR current was also observed 2 days after withdrawal, mediated by removal of GluN1/GluN2B-containing NMDARs from CA1 PSDs [20], which normalized total excitatory current output in CA1 neurons and precluded expression of withdrawal anxiety [16, 19, 21]. The gene discussed is GRIN2B; the disease is Anxiety.