Impairment of IRS2 expression (but not in IRS1) in monocyte cells was demonstrated in first-degree relatives of type 2 DM patients [15] The objective of this study is to determine the expression of IRS1 in peripheral leukocytes (IRS1 cells) of HCV-infected patients and in a control group (blood donors), correlating it with the expression of IRS1 in the liver (IRS1 liver) and the presence of insulin resistance. Here, IRS1 is linked to Insulin resistance.