The decreased calcium sensitivity was also reported for DCM-causing mutations in alpha-tropomyosin (TPM1) [44] and cardiac troponin C (TNNC1) [45], whereas the increased calcium sensitivity was noted for various HCM-causing mutations in the contractile element genes, including TPM1 [44, 46], cardiac troponin I gene (TNNI3) [47], ventricular myosin regulatory light chain gene (MYL2) [48], and MYBPC3 [49]. The gene discussed is TNNC1; the disease is familial dilated cardiomyopathy.