Interestingly, Grzeschik and collaborators showed that the depletion of the Drosophila neoplastic tumor suppressor Lethal giant larvae (Lgl), which controls apical-basal cell polarity and proliferation, leads to upregulation of the Hippo pathway target Yki through a decreased phosphorylation and consecutively overproliferation of developing eyes, without affecting apical-basal polarity [43]. Here, YAP1 is linked to neoplasm.