Previously, Shahbazi et al. identified a G to A polymorphism at position 61 (+61G/A, rs4444903) in the 5′-untranslated region of EGF, and the presence of the variant A allele led to a decreased EGF production in peripheral blood mononuclear cells cultures, glioblastoms, and gliomas cell lines [8], [9]. The gene discussed is EGF; the disease is central nervous system cancer.