Recent research has shown that the ACSL1 rs9997745 polymorphism influences the risk of metabolic disease, most likely via disturbances in FFA metabolism [16]; no individual or combined association was however found for other SNPs of this gene, i.e. rs4862417, rs13120078, rs12503643 and the one we studied here, rs6552828. The gene discussed is ACSL1; the disease is metabolic disease.