Previous papers reported positive immunoexpression of p53 protein [8], [9], yet TP53 mutations seem to be infrequent events in pleomorphic adenomas (PA), adenoid cystic carcinomas (ACC), mucoepidermoid carcinomas (MEC) and carcinomas ex pleomorphic adenomas (CAexPA) [10], [11], [12], [13], [14]. The gene discussed is TP53; the disease is adrenal cortex carcinoma.