THY1 and ganglioneuroma: In Thy1 GN, PIASy and E12 were upregulated and distributed similarly in the nucleus of the glomerulus in the proliferative phase, along with increased α-SMA and TGF-β expression, suggesting that these genes were involved in the regulation of α-SMA under pathophysiological conditions in vivo, and that tight control of HLH levels and activity by PIASy is necessary to prevent uncontrolled cell proliferation and dedifferentiation.