ERBB2 and breast carcinoma: Additionally, miR-194 was not induced by trastuzumab treatment in either the MDA-MB-231 breast cancer cell line that expresses low levels of HER2 and is insensitive to trastuzumab or the KPL4 breast cancer cell line that expresses high levels of HER2 and is insensitive to trastuzumab (Fig. S2).