RNASET2 and neoplasm: In eukaryotic cells, T2 ribonucleases affect a variety of processes including the regulation of self-incompatibility by S-RNases in plants [1]–[4], modulation of host immune cell responses by viral and schistosome T2 enzymes [5]–[9], and neurological development [10] and tumor progression in humans [11], [12].